Acetylsalicylic acid is very well-known as the drug Aspirin and is used to reduce pain and fever. It is also supplied under other brand names, such as Acylpyrin or Anopyrin. This application note shows the determination of impurity – salicyclic acid in the final product.
The accurate, simple, and selective HPLC/UV method has been established and validated for the determination of the antibiotic AMP as a suitable method in a cardiac surgery which does not have to be used only in cardiac surgery. The new ARION® Polar C18 column has been shown to effectively separate AMP in human blood plasma.
Avenanthramides (AVN) are phenolic alkaloids that are found mainly in oats. They are used in various diary supplements and dermatology products thanks to their anti-inflammatory effects and antioxidant activities.
Citrate is a chemical stabilizer used in infusion solutions. However, infusion of citrate is responsible for a decrease of arterial blood preessure. So, it is very important to keep optimum concentration in citrate infusion.
Xanax is an benzodiazepine alprazolam-based anxiolitic. Counterfeit Xanax may contain caffeine as a main component, as well as clonazolam and flualprazolam, both of which have a strong sedative effect, are able to cause amnesia, and belong to the group of new psychoactive drugs.
The development of the HPLC method for vitamin mixtures in drug products is always challenging, taking into account the requirements of analytical methods in pharmaceutical production. Shown below is a chromatogram of dissolution profile of tablets that contain a mixture of pyridoxine hydrochloride and benfotiamine. ARION® Polar C18 column provides a perfect resolution factor and peaks symmetry in a long sequence of analysis.
Ergot alkaloids are mitotoxins produced by several species of fungies. Many different cereals may become contaminated with ergot alkaloids that cause poisoning in human and animals is known as ergotism. Despite on actions taken in agricultural practice for grain purification, control of the ergot alkaloids is still actual taking into account the low toxicological limits of these mitotoxins.
The levels of the degradation product, 5-hydroxymethylfurfural (5-HMF), in Dextrose Injection is an important determination in pharmaceutical formulas and pharmacokinetic studies. ASTRA® DM shows better retention for polar compounds.
Ibuprofen is a substance from a group of non-steroidal anti-inflammatory drugs. In order for the drug release to be targeted on the basis of pH change (gradual release for up to 30 days), binding to a polymeric carrier is used.
Ipidacrine is a drug inhibitor of acetylcholinesterase produced for the treatment of memory disorders caused by various diseases. This drug was first synthetized by the National Research Centre for Biologically Active Compounds (Russian Federation).
Prostaglandin Active Pharmaceutical Ingredients (APIs) play a significant role in the bodies of humans and animals, and therefore are synthetised for use in ophthalmology, veterinary, and vascular treatment.
A Quinolone antibacterials are drugs used in veterinary medicine to treat bacterial infections. The analysis of residual amounts of drugs in food is important for monitoring the quality control of products of animal origin. This application clearly shows the separation of 16 quinolones using the LC/MS technique.
Tamsulosin hydrochloride is used to treat the symptoms of an enlarged prostate. This drug is an alpha-blocker that works by relaxing the muscles in the prostate and the bladder. Tamsulosin is sold under various trade names, e.g. Flomax, Urimax, Contiflo XL, Mesir LP, Prostanil MR, Tamsin, Fokusin, etc. The application note shows the chromatogram of the determination of the tamsulosin hydrochloride content according to the proprietary method.
Vitamin D is a group of steroids that have various effects on the human body and support the immune system. This application shows LC/MS/MS separation of the hydroxylated and non-hydroxylated forms of vitamin D2 and vitamin D3. The amount of their hydroxylated forms determines the total vitamin D in a blood sample. Non-hydroxylated forms of vitamin D2 and vitamin D3 are important for food analysis. The LC/MS/MS chromatogram shows the separation of all the above mentioned analytes.
Voriconazole and Posaconazole are antifungal drugs that are monitored in plasma and urine. Spiked samples based on a blood plasma from blood donors at transfusion station were used in this application note.