Analysis of small polar compounds (APK #603)

Using of reversed phase liquid chromatography for analysis of small polar compounds is challenging. Often the derivatization step is needed that cause a longer sample preparation and problem with accuracy and precision of the method. A better option to separate polar analytes is to use hydrophilic interaction LC. ASTRA^® Si column allows to separate such polar compound as metformin, guanylurea and melamine. HILIC technique can be applicable in the toxicological, pharmaceutical, and environmental fields where analysis of small polar compounds is required.

• APP_NOTE_603_Analysis of small polar compounds 2221 kB