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Related substances of cefazolin sodium (APK #516)

Separation of impurities with close structure is always challenging in pharmaceutical industry due to the strict requirements to acceptance criteria of chromatographic method and low limits for impurities quantification. This application shows the method for determination of related substances of cefazolin sodium by the Ph. Eur. Monograph. ARION® Polar C18 column allows to separate all impurities according to the method.