A gradient LC/MS method was developed for rapid determination of several classes of cardiovascular drugs such as non-cardioselective beta blockers, potassium-sparing diuretics, statins, nucleoside transport inhibitors, calcium channel blockers, ACE inhibitors, ARBs, lipid-lowering agents and anticoagulants.
This application describes a fast and robust LC-MS/MS method for the analysis of estrone and estradiol, two naturally occurring estrogens in the human body. There are three types of estrogen: estrone, estradiol, and estriol. Each plays an important role in a specific aspect of our lives.
Estradiol is important for reproduction in women and, to some extent, in men as well, and it also affects, for example, bone density, skin, and mood. Estriol is important during pregnancy for the proper development and support of the fetus. Estrone plays a major role in women during menopause.
That is why it is important to accurately measure the levels of these substances in the liver, and our Astra® c18-hybrid column can help with this.
1607 kBA quantitative determination of steroids is a valuable tool in a clinical practice in diagnostic of the steroid-related diseases. This method shows the simultanious analysis of wide panel of steroids by sensitive LC-MS/MS method.
2067 kB