Sorbents for the MSPE technique are chosen to cover the widest possible field of applications. MSPE SpeExtra C18 is a hydrophobic type of octadecyl silica gel with a special endcapping. It is suitable for a wide range of analytes, showing lower retention for polar compounds. MSPE SpeExtra C18-P is a polar modified monomeric octadecyl silica gel. It offers different types of interactions: dipole-dipole, π-π and hydrophobic. It is therefore suitable for aromatic and polar compounds. MSPE SpeExtra HLB polymer sorbent with high specific surface area and special endcapping. It has a hydrophilic and lipophilic modification ensuring universal use and a higher capacity than C18 silica gel.