Chromatographers always seek to push the limits of HPLC columns to greater extremes to allow them to perform day-to-day with ever-changing pH, buffers and temperature ranges. The column for the laboratory of today must be suitable for harsh pH conditions in combination with high temperature ranges without sacrificing selectivity. In addition narrow, symmetrical peak shapes are necessary in order to cope with rapid analysis of demanding samples. This has required manufacturers to seek more innovative ways to produce suitable stationary phases.
In order to meet these goals, YMC has developed a new particle technology. This is based on a multi-layered particle produced via a tightly controlled granulation technology which has been adapted from micro-reactor technology. The revolutionary production technique provides a multi-layer silica-organic hybrid stationary phase, which provides an outstandingly narrow pore size and particle size distribution. This in turn, results in low back pressures and high loadability.