Glassware deactivation with DMDCS
Dimethyldichlorsilane (DMDCS) reacts with active hydroxyl groups present on glass surface producing a deactivated layer. This ensures inert glassware used for sensitive compounds.
During the deactivation process, the reaction releases hydrogen chloride (HCl). So we strongly recommend to do this procedure in a fume hood.
- Use 5% DMDCS solution in toluene. You can prepare this solution by diluting 20 ml of DMDCS with 400 ml toluene. Store the solution in an amber glass at room temperature.
- Soak glassware in 5% DMDCS solution for 15 to 30 minutes.
- Rinse glassware twice with toluene.
- Soak glassware in methanol for 15 minutes.
- Rinse glassware with methanol.
- Dry glassware with high purity nitrogen (moisture and hydrocarbon free).