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Glassware deactivation

Glassware deactivation with DMDCS

Dimethyldichlorsilane (DMDCS) reacts with active hydroxyl groups present on glass surface producing a deactivated layer. This ensures inert glassware used for sensitive compounds.


During the deactivation process, the reaction releases hydrogen chloride (HCl). So we strongly recommend to do this procedure in a fume hood.

  • Use 5% DMDCS solution in toluene. You can prepare this solution by diluting 20 ml of DMDCS with 400 ml toluene. Store the solution in an amber glass at room temperature.
  • Soak glassware in 5% DMDCS solution for 15 to 30 minutes.
  • Rinse glassware twice with toluene.
  • Soak glassware in methanol for 15 minutes.
  • Rinse glassware with methanol.
  • Dry glassware with high purity nitrogen (moisture and hydrocarbon free).

Hints and tips

LaboratoryThis site includes technical information, hints and tips for your decisions, and recommendation for selecting right chromatography accessories.

Syringe tip selection

The selection of suitable syring tip is mentioned in Hamilton catalogue. Please, ask for this catalogue.

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